Dr. Michelle Hamm
Professor of Chemistry
Chair, Department of Chemistry
I use synthetic and physical organic chemistry to address specific biological questions. Currently, my work focuses on 8-oxo-2'-deoxyguanosine (OdG), an abundant DNA lesion that can cause genome mutation and is thought to play a major role in several diseases, including cancer. My group is synthesizing analogs of OdG and incorporating them into short strands of DNA. These analogs have great potential as biochemical tools with which to study the contacts that take place between OdG lesions and other biopolymers. For example, we will use these molecules to study how various nucleotides and enzymes, including polymerases and glycosylases, interact with OdG at the molecular level. These studies will help reveal not only how these lesions lead to DNA mutations, but also how the mutations are prevented and/or removed by DNA repair enzymes. Furthermore, since it has been hypothesized that mutations produced by OdG may trigger the associated diseases, these studies may also provide insight into the link between disease and OdG.
Grants and Fellowships
Research Corporation Multi-Investigator Cottrell College Science Award; $100,000; 7/1/13- 6/30/15; with Eugene Wu in the University of Richmond Biology Department
National Science Foundation- RUI Award; $255,000; 9/1/13-8/31/16
Henry Dreyfus Teacher-Scholar Award; $60,000; 11/1/07-10/31/18
2013 University of Richmond School of Arts and Sciences Mentor Award
2013 Rising Star Award from the Women’s Chemists Committee of the American Chemical Society
2007 University of Richmond Distinguished Educator Award
Hamm, M.L.; Crowley, K.A.*; Ghio, M.*; Lindell, M.A.M.*; McFadden, E.J.*; Silberg, J.S.L.*; Weaver, A.M.* Biochemical Investigations into the Mutagenic Potential of 8-Oxo-2’-deoxyguanosine using Nucleotide Analogues. Chem. Res. Toxicol. (2012) 25, 2577-2588
Hamm, M.L.; Crowley, K.A.*; Ghio, M.*; Del Giorno, L.*; Gustafson, M.A.*; Ligon, C.W.*;Kindler, K.E.*; Lindell, M.A.M.*; McFadden, E.J.*; Siekavizza-Robles, C.*; Summers, M.R.*Importance of the C2, N7, and C8 Positions to the Mutagenic Potential of 8-Oxo-2′-deoxyguanosine with Two A Family Polymerases. Biochemistry (2011) 50, 10713-10723.
Hamm, M.L.; Parker, A.J.*; Steele, T.W.*; Carman, J.L.*; Parish, C.A. Oligonucleotide Incorporation and Base Pair Stability of 9-Deaza-2’-deoxyguanosine, an Analogue of 8-Oxo-2’-deoxyguanosine. J. Org. Chem (2010) 75, 5661-5669.
Hamm, M.L.; Gill, T.J.*; Nicolson, S.C.*; Summers, M.R.* Substrate Specificity of Fpg (MutM) and hOGG1, Two Repair Glycosylases J. Amer. Chem. Soc. (2007) 129, 7724 - 7725.
Hamm, M.L.; Billig, K.* Oligonucleotide Incorporation and Base Pair Stability of 7-Methyl-8-oxo-2'-deoxyguanosine. Org. Biomol. Chem. (2006) 4, 4068-4070.
Hamm, M.L.; Rajguru, S.*; Downs, A.M.*; Cholera, R.* Base Pair Stability of 8-Chloro and 8-Iodo-2'-deoxyguanosine Opposite 2'-Deoxycytidine: Implications regarding the Bioactivity of 8-Oxo-2'-deoxyguanosine. J. Amer. Chem. Soc. (2005) 127, 12220-12221.
Hamm, M.L.; Cholera, R.*; Hoey, C.L.*; Gill, T.J.* Oligonucleotide Incorporation of 8-Thio-2'-deoxyguanosine Org. Lett. (2004) 6, 3817-3820.
Alecseyev Y., Hamm, M.L., and Essigmann J.M. Aflatoxin B1 Formamidopyrimidine Adducts are Preferentially Repaired by the Nucleotide Excision Repair Pathway in vivo. Carcinogenesis (2004) 25, 1045-1051.
Smela, M.E., Hamm, M.L., Henderson, P.T., Harris, C.M., Harris, T.M., and Essigmann, J.M. The Aflatoxin B1 Formamidopyrimidine Adduct Plays a Major Role in Causing the Types of Mutations Observed in Human Hepatocellular Carcinoma. Proc. Natl. Acacd. Sci. USA (2002) 99, 6655-6660.